Ole Miss vs. LSU CFB Week 7 Prediction, Odds, Best Bets

Night games in Death Valley offer some of the best conditions in college football, and fans can look forward to LSU taking on Ole Miss in a CFB Top 15 matchup in Week 7.

Ninth-ranked Ole Miss vs. No. 13 LSU gets lost in the shuffle of a slate full of must-see matchups. When these teams met last season, it was a 55-49 game that went down to the final whistle.

Saturday night is one of the rare times LSU is an underdog at Tiger Stadium.

Ole Miss vs. LSU prediction and best bets

• LSU +3.5: -115 odds at Fanatics Sportsbook
• Caden Durham all-time touchdown scorer: -110 odds at BetMGM Sportsbook

Head coach Lane Kiffin and the Rebels may have a better AP poll rating than the Tigers, but there are a few reasons to believe in LSU.

The Tigers haven't left Baton Rouge since Sept. 14 and should be fresh thanks to last week's bye. The Rebels didn't have a bye yet and traveled to South Carolina a week ago.

Ole Miss defeated LSU in 2023 and the Rebels have not defeated the Tigers in consecutive seasons since 2008-2009. LSU's last loss in Death Valley came in 2022, and head coach Brian Kelly's team is hard to beat in night games at home.

Last but not least: The home team is 7-2 in the last nine meetings between Ole Miss and LSU.

The Rebels could be without star WR Tre Harris, who leads the FBS in receiving yards by a wide margin. Ole Miss' next three WRs – Antwane Wells Jr., Cayden Lee and Jordan Watkins – have fewer receiving yards combined than Harris.

When Harris takes the field, it's hard to imagine he'll be at 100%.

LSU at +3.5 is an excellent value, and the team's moneyline odds deserve consideration (+140 at Fanatics Sportsbook).

I also like LSU RB Caden Durham's all-time touchdown scoring odds. Durham is tied for the team lead in touchdowns and has scored in three straight games.

The smaller defender is also a threat in the passing game, as he has two touchdown catches this year.

Ole Miss vs. LSU CFB Week 7 Odds

According to PFF Greenline, most bettors like Ole Miss on Saturday night. About 70% of the money bet is directed at the Rebels covering the spread.

TeamRankings reports that LSU has been brutal against the spread, covering in just one game. Ole Miss now owns an ATS record of 5-1.

Even though they scored a total of 104 points last season, most bettors are betting on the lower limit. The Rebels have a productive offense, but the over has only hit in one Ole Miss game.

Ole Miss vs. LSU Moneyline Odds Analysis

Why Ole Miss is the favorite to win

Best odds: -162 at DraftKings Sportsbook

The Ole Miss offense thrives on big plays and QB Jaxon Dart leads CFB with 12.1 yards per completion. The Heisman hopeful ranks second in passing yards with just two interceptions.

However, Dart and the Rebels' pass catchers will have to step up their game if Harris can't go. Ole Miss' WR team is talented but didn't get a chance to prove itself because Harris was dominant.

LSU also has a top-notch offense and Ole Miss' defense appears to be up to the challenge. The Rebels have the most sacks in the country and give up the third fewest points per game.

Why LSU can win as an underdog

Best odds: +140 at bet365 sportsbook

The Tigers can slow down the Rebels' pass rushers with an offensive line that gave up two sacks – the fourth-best mark in the FBS.

LSU started the season with a loss and was largely defeated by underperforming teams, but Week 3 was an exception. The Tigers earned a courageous road win over South Carolina after starting the game trailing 17-0.

Another big performance from QB Garrett Nussmeier is a necessity against Ole Miss' outstanding offense. Nussmeier has thrown for more than 300 yards and multiple touchdowns in all but one game this year.

LSU has struggled to score the ball accurately this season, and that likely won't change against a defense that allows the fewest rushing yards per game. This puts more responsibility on Nussmeier.