Detroit Lions vs. Tennessee Titans

▶Nolan Bianchi: The Lions are on a six-game losing streak against two teams (Seattle Seahawks and Dallas Cowboys) this season. Why not another one? Detroit has never beaten the Titans since moving to Tennessee in 1999, but they are heavy favorites for their first home game in nearly a month. On paper, it shouldn't be anywhere near that. But even on paper: Tennessee's defense has been fantastic this year. The Lions might have a little more trouble offensively than initially thought, but in the end they should have enough firepower to overcome this with ease. Pick: Lions, 27-10

▶ Richard Silva: Tennessee launched its fire sale this week, sending receiver DeAndre Hopkins to the Kansas City Chiefs and linebacker Ernest Jones IV to the Seattle Seahawks. Players and coaches aren't backing down, but nothing is stopping front offices from looking at the writing on the wall and waving the white flag on the season. The Titans are one of the worst teams in the NFL and the Lions are among the best. Anything can happen, but the talent gap is too big to predict anything other than a Detroit win. Pick: Lions, 35-24