Our CFB picks for Week 6: Will Oregon cruise? Will Oregon State win? Michigan or Washington?

The Big Ten's top three teams are each at home this week as the college football season continues with a series of entertaining matchups in Week 6.

No. 3 Ohio State hosts Iowa, while No. 6 Oregon faces Michigan State in Eugene and No. 7 Penn State faces inferior UCLA.

• REGARD: Stream most of this week's top college football games live for FREE with Fubo (free trial version) or with DirecTV stream (free trial).

Meanwhile, No. 10 Michigan takes on Washington at Husky Stadium and 11th-ranked USC visits Minnesota.

In the Pac-12, Oregon State hosts Colorado State on Saturday afternoon at Reser Stadium.

Will all five top-ranked Big Ten teams pick up wins while covering the gap? Will the Beavers take care of the Rams?

Check out this week's college football odds and score predictions for select games from the CFB coverage team at The Oregonian/OregonLive.

Michigan State (3-2, 1-1) at No. 6 Oregon (4-0, 1-0)

Game details: Friday, 6:00 p.m. PT at Autzen Stadium in Eugene

TV channels and live stream: Fox and Fox Sports Live

Latest line: Oregon until May 23rd

Over/Under: 51.5

Predictions

Ryan Clarke: Oregon 35, Michigan State 17

James Crepea: Oregon 35, Michigan State 14

Nick Daschel: Oregon 45, Michigan State 24

Aaron Fentress: Oregon 47, Michigan State 17

Joe Freeman: Oregon 31, Michigan State 17

Sean Meagher: Oregon 42, Michigan State 14

Joel Odom: Oregon 44, Michigan State 27

Bill Oram: Oregon 38, Michigan State 13

Colorado State (2-2) and Oregon State (3-1)

Game details: 3:30 p.m. PT Saturday at Reser Stadium in Corvallis

TV channels and live stream: The CW

Latest line: Oregon State at 11

Over/Under: 47.5

Predictions

Ryan Clarke: Oregon State 31, Colorado State 21

James Crepea: Oregon State 35, Colorado State 14

Nick Daschel: Oregon State 27, Colorado State 13

Aaron Fentress: Oregon State 31, Colorado State 6

Joe Freeman: Oregon State 27, Colorado State 14

Sean Meagher: Oregon State 31, Colorado State 17

Joel Odom: Oregon State 34, Colorado State 17

Bill Oram: Oregon State 17, Colorado State 7

UCLA (1-3, 0-2) at No. 7 Penn State (4-0, 1-0)

Game details: 9 a.m. PT Saturday at Beaver Stadium in University Park, Pennsylvania

TV channels and live stream: Fox and Fox Sports Live

Latest line: Penn State until May 28th

Over/Under: 46.5

Predictions

Ryan Clarke: Penn State 50, UCLA 10

James Crepea: Penn State 42, UCLA 14

Nick Daschel: Penn State 38, UCLA 7

Aaron Fentress: Penn State 57, UCLA 17

Joe Freeman: Penn State 35, UCLA 14

Sean Meagher: Penn State 38, UCLA 7

Joel Odom: Penn State 49, UCLA 10

Bill Oram: Penn State 45, UCLA 10

Purdue (1-3, 0-1) at Wisconsin (2-2, 0-1)

Game details: 9 a.m. PT Saturday at Camp Randall Stadium in Madison, Wisconsin

TV channels and live stream: Big Ten Network and Fox Sports Live

Latest line: Wisconsin at 12.5

Over/Under: 45.5

Predictions

Ryan Clarke: Wisconsin 31, Purdue 24

James Crepea: Wisconsin 28, Purdue 21

Nick Daschel: Wisconsin 34, Purdue 10

Aaron Fentress: Wisconsin 37, Purdue 13

Joe Freeman: Wisconsin 30, Purdue 14

Sean Meagher: Wisconsin 35, Purdue 14

Joel Odom: Wisconsin 42, Purdue 17

Bill Oram: Wisconsin 24, Purdue 14

Iowa (3-1, 1-0) at No. 3 Ohio State (4-0, 1-0)

Game details: 12:30 p.m. PT Saturday at Ohio Stadium in Columbus

TV channels and live stream: CBS and Paramount+

Latest line: Ohio State until May 18th

Over/Under: 45.5

Predictions

Ryan Clarke: Ohio State 38, Iowa 13

James Crepea: Ohio State 35, Iowa 17

Nick Daschel: Ohio State 27, Iowa 12

Aaron Fentress: Ohio State 49, Iowa 20

Joe Freeman: Ohio State 31, Iowa 17

Sean Meagher: Ohio State 45, Iowa 13

Joel Odom: Ohio State 31, Iowa 10

Bill Oram: Iowa 28, Ohio State 27

No. 23 Indiana (5-0, 2-0) at Northwestern (2-2, 0-1)

Game details: 12:30 p.m. PT Saturday at Lanny and Sharon Martin Stadium in Evanston, Illinois

TV channels and live stream: Big Ten Network and Fox Sports Live

Latest line: Indiana at 14

Over/Under: 41.5

Predictions

Ryan Clarke: Indiana 41, Northwest 24

James Crepea: Indiana 56, Northwest 14

Nick Daschel: Indiana 40, Northwest 27

Aaron Fentress: Indiana 29, Northwest 19

Joe Freeman: Indiana 27, Northwest 13

Sean Meagher: Indiana 41, Northwest 13

Joel Odom: Indiana 28, Northwest 7

Bill Oram: Indiana 20, Northwest 0